A blog about what is new (and old) in the world of active implantable medical devices 

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CCC del Uruguay’s Early Mercury-Cell Pacemaker (1969)

1969 CCC del Uruguay Pacemaker

This is one of my most prized possessions.  It is one of the very first pacemakers produced by CCC del Uruguay in 1969.  It was given to me by my friend, the late Dr. Orestes Fiandra, founder of CCC del Uruguay.

On February 2, 1960, Dr. Orestes Fiandra and Dr. Roberto Rubio accomplished the first succesful long-term human implant of a pacemaker. The pacemaker was manufactured by Dr. Rune Elmqvist of Elema-Schönander in Sweden, and was implanted in Uruguay in a 34-year-old patient with AV block. This unit worked successfully for nine and a half months, until the patient died of sepsis from an unrelated infection.

In 1969, Dr. Fiandra started the “Centro de Construccion de Cardioestimuladores del Uruguay” (CCC for short) with the purpose of producing pacemakers for use in Latin America at prices well under those of American devices.  The device in the photograph above is one of these devices – a simple VOO pacemaker powered by 5 mercury cells encapsulated in epoxy resin.

 

 
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CCC Medical – Top OEM to AIMD Start-Ups

CCC del Uruguay Teros SSI pacemaker model 503CCC is one of the oldest pacemaker manufacturers in the world. It was founded in 1969 by Dr. Orestes Fiandra, who performed the first succesful, human, long-term pacemaker implant in the world.

This was achieved in Uruguay on February 2, 1960 by Dr. Orestes Fiandra and Dr. Roberto Rubio. The pacemaker was manufactured by Dr. Rune Elmqvist of Elema-Schönander in Sweden, and was implanted in Uruguay in a 34-year-old patient with AV block. This unit worked successfully for nine and a half months, until the patient died of sepsis from an unrelated infection. Read more…

 
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Omikron Scientific – Israeli Pacemaker Company (1979-1985)

Omikron Scientific Model 811 Pacemaker

Omikron Scientific was a small-scale pacemaker company founded in Rehovot, Israel in 1979.  The company stopped pacemaker production in 1985.

Besides pacemakers, Omikron also produced a skin substitute called Omniderm, which was a thin, transparent, flexible membrane. It was used when a biological dressing would otherwise have been used.

Omikron’s pacemakers were all VVI and featured gradual decline Magnet Rate & Programmed Rate.  Models included the 811 (6.5 year longevity), 811L (10 year longevity), 811XL (14 year longevity), 821 (VVIM with 8 year longevity), 837, a 838 (6.5 year longevity).

Click here for Omikron’s patents.

 
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MicroTransponder’s Injectable Stimulators

 

MicroTransponder's concept for injectable microstimulators

From US Patent Application Publication US 2009/0163889 A1

 

MicroTransponder was founded in Dallas, TX in  2007 when it licensed technology developed at University of Texas in Dallas (UTD) by Larry Cauller, who heads the cortical connections lab. The first wireless transponder was developed under a DARPA Revolutionizing Prosthetics grant to create a bi-directional neural interface for a prosthetic hand. Read more…

 
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Northstar Neuroscience’s Renova Cortical Stimulation System (1999-2009)

Northstar's Renova Implantable Stimulator for the Treatment of Stroke

Northstar was founded in 1999 as Vertis Neuroscience headquartered in Seattle, WA, and the original goal was to develop electrical stimulation for chronic back pain.  In 2003, under its new name, Northstar Neuroscience, then developed the Renova cortical stimulation system to deliver targeted electrical stimulation to the brain cortex as a treatment for stroke-related upper extremity. Read more…

 
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Intrapace Abiliti Gastric Stimulator for the Treatment of Obesity

Intrapace Ability IPG for Treatment of ObesityIntrapace was founded in Mountain View, CA by Mir Imran in 2001 to develop an implantable system for the treatment of obesity.  Once implanted and activated, the Abiliti system is designed to detect when a person consumes food or drink. When food or drink is detected, the system delivers a series of low-energy electrical impulses to the stomach intended to create a feeling of fullness.

In January 2011 Intrapace received the CE Mark for the Ability system.

The Ability IPG connects to the stomach via a lead that integrates the food sensor and stimulation electrodes. The sensor is able to detect food and drink and can trigger the abiliti stimulator device to create a feeling of fullness. These eating events, along with physical activity the patient engages in, are automatically recorded and available for downloading to a personal computer using the connect.abiliti Wand. Read more…

 
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Transneuronix Transcend IPG for Obesity Treatment

Transneuronix Transcend Implantable Gastric Stimulator for Treatment of ObesityTransneuronix, Inc. was founded in 1995 and was based in Mount Arlington, New Jersey. It was acquired by Medtronic in 2005.

Before its acqusition by Medtronic, Transneuronix developed the Transcend, an implantable gastric stimulator device for the treatment of obesity by electrical stimulation of the stomach.  Later, Medtronic developed the Transcend II IPG. Read more…

 
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EnteroMedics’ Maestro RC Vagus Nerve Stimulator for Obesity Management

EnteroMedics Inc. was founded in St. Paul, MN in 2002 to develop a platform for vagus-nerve stimulation, primarily for obesity management.  In March 2011 EnteroMedics received the CE Mark for its second-generation system – the Maestro RC.

The EnteroMedics Maestro RC device delivers VBLOC® vagal blocking therapy to through laparoscopically implanted leads to intermittently block the vagus nerves using high-frequency, low-energy electrical impulses. VBLOC Therapy is intended to target the multiple digestive functions under control of the vagus nerves and to affect the perception of hunger and fullness. Read more…

 
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Transoma’s Sleuth Implantable Wireless ECG Monitor

Transoma's Sleuth Implantable Wireless ECG MonitorTransoma was the name that Data Sciences International of St Paul, MN adopted in 2003 when it re-fucused its animal telemetry implant business to develop an implantable wireless system to capture electrocardiogram data for diagnosing human cardiac arrhythmias, as well as to monitor the electrical activity of the heart and transmit data from the patient’s home to monitoring centers.

In 2007, Transoma received FDA’s approval for its Sleuth implantable device to wirelessly monitor a patient’s ECG for possible diagnosis of arrhythmias and prevention of syncopal episodes.  The Sleuth ECG Monitoring System included a High Definition Implantable Loop Recorder (HD-ILR), a Personal Diagnostic Manager, a Base Station and a Monitoring Center staffed 24/7. Read more…

 
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CerebralRx FitNeS Vagus Nerve Stimulator for Epilepsy Treatment

CerebralRx FitNeS vagus neurve stimulator for treatment of epilepsy

Image Credit: Biocontrol

In June 2011, Israeli neuromodulation systems developer BioControl Medical spun-off CerebralRx to market its FitNeS vagus nerve stimulation system for the treatment of refractory epilepsy.

The FitNes system employs platform technology developed for the CardioFit® system for treating congestive heart failure (HF). CerebralRx spun out of BioControl Medical to expand the use of this technology outside of cardiology for the treatment of a range of neurological disorders, including epilepsy.

Read more…

 
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Enopace Biomedical

Enopace's implantable device

From Patent Application Publication: US 2011/0137370 A1

Enopace Biomedical Ltd. was founded in 2008 by Yossi Gross in Caesarea, Israel.

Very scant details are available besides that it is developing a neuromodulation system to treat patients with congestive heart failure. According to the company, its technology consists of a minimally invasive, implantable neurostimulation device that increases cardiac efficiency by reducing left ventricular workload.

From Enopace’s patent applications, it seems that Enopace’s device consists of a stimulation unit that is placed within the aorta close to the heart, and which is driven wirelessly from a coil that is placed within a vein closeby to the artery.  The transmitting coil is in turn driven from an implanted control unit that is implanted subcutaneously. Read more…

 
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CVRx Implantable Baroreflex Stimulator for the Treatment of Hypertension

 

CVRx neo Implantable Stimulator for the Treatment of Hypertension

Image Credit: CVRx

 CVRx was founded in Minneapolis, MN in 2001 by Dr. Robert Kieval to develop an implantable system for the treatment of hypertension.

CVRx’s implantable pulse generators deliver stimulation to the baroeceptors in the carotid arteries to induce a baroreflex that causes a drop in blood pressure in patients with refractory hypertension. Read more…

 
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Second Sight’s Implantable Retinal Prosthesis

Second Sight Medical Products, Inc., located in Los Angeles, CA, was founded in 1998 by Alfred Mann to develop a retinal prosthesis to provide sight to patients blinded from outer retinal degenerations, such as Retinitis Pigmentosa.

Second Sight’s Argus II Retinal Prosthesis System is intended to provide electrical stimulation of the retina to induce visual perception in blind individuals. The implant is an epiretinal prosthesis surgically implanted in and on the eye that includes an antenna, an electronics case, and an electrode array. The external equipment includes glasses, a video processing unit (VPU) and a cable.

Read more…

 
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EndoStim Implantable Stimulator for Treatment of Gastro-Esophageal Reflux Disease (GERD)

EndoStim IPG for treatment of GERD

© 2011 David Prutchi

St. Louis, MO startup EndoStim is developing an implantable stimulator to treat gastro-esophageal reflux disease (GERD) by delivering stimulation to the lower esophageal sphincter.  The IPG is connected to an EndoStim implantable bipolar lead with electrodes that are stitched and secured into the lower esophageal sphincter muscle during laparoscopy. Read more…

 
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Sicel’s Implantable Radiation Dosimeter

Sicel Technologies, Inc. was founded in 1999 and was based in Morrisville, NC. It ceased operations in 2010 after it declared bankruptcy.

Sicel developed an implantable dosimeter that was 2 mm in diameter and 18 mm long, and was injected into the tumor to send back readings to an external receiver via RFID. Read more…

 
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