Angel Medical was founded by Dr. Robert E. Fischell and Dr. David R. Fischell. The AngelMed Guardian® system is an implantable cardiac device, designed to detect rapid ST segment shifts that may signify major cardiac events, such as coronary artery occlusions caused by life-threatening vulnerable plaque ruptures. Once an ST shift is detected, the system is designed to alert patients to seek medical care by delivering a series of vibratory, auditory, and visual warnings. The AngelMed Guardian system is intended to address the challenge of patients not recognizing nor responding quickly to heart attacks. Continue reading
Brainsgate‘s implantable pulse generator is designed to stimulate the Spheno-Palatine Ganglion. It is activated by an external transcutaneous energy transmitter. Brainsgate is evaluating the system’s capability to augment cerebral blood flow as a treatment of ischemic stroke or dementia. Continue reading
Yossi Gross (born February 5, 1947) is an Israeli medical device innovator and entrepreneur. His medical-device companies are incubated through Rainbow Medical.
Currently, the following companies led by Yossi Gross are focusing on active implantable medical devices:
- BetaStim, developing a new neurostimulation treatment for diabetes
- Brainsgate, developing an implantable device for acute stroke treatment and brain drug-delivery technology
- BioControl Medical, developing neurostimulation devices
- Enopace Biomedical, developing implantable devices for heart failure treatment through stimulation of the aorta
- CerebralRx, a spin-off from Biocontrol developing vagus nerve stimulators for the treatment of epilepsy
Dr. Shlomo Ben-Haim has held faculty appointments as a Professor of Medicine, Physiology and Biophysics, at both Harvard University and the Technion – Israel Institute of Technology. His formal education is in the fields of nuclear physics, mathematics, biomedical engineering, philosophy, and medicine. Dr. Ben-Haim has published his research in over 100 scientific papers, in peer-reviewed journals. He holds over 180 patents and patent applications.
Currently, two companies led by Dr. Ben-Haim are focusing on active implantable medical devices:
Mir A. Imran (born 1956, Hyderabad, India), is an Indian entrepreneur and venture capitalist. Imran has formed 19 companies since the early 80s and holds over 140 patents. He is the founder and Chairman of InCube Laboratories, Inc., a research laboratory and business incubator for medical and technology companies
Currently, four InCube companies are focusing on active implantable medical devices:
- Intrapace, which is developing an implantable device to treat obesity
- Spinal Modulation, which is developing a novel therapy for the management of chronic pain with an implantable microstimulator
- Neurolink, which is developing a novel therapy for epilepsy
- Corhythm, which is focused on the treatment of AFIB
Spinal Modulation is a company based in Menlo Park, CA. It has developed a neurostimulator for chronic intractable pain management.
According to the company, the Spinal Modulation System utilizes low-level electrical signals to modulate neural structures of primary sensory neurons located within the dorsal root ganglion (DRG). These cell bodies have been implicated in the development and maintenance of chronic pain conditions. Continue reading
Morgan Technical Ceramics (MTC) announced that its Bedford, Ohio site manufactures the piezoelectric ceramic materials used in EBR Systems, Inc.’s innovative new WiCS® Wireless Cardiac Stimulation System. The PZT (lead zirconate titanate) material made by MTC is critical to the efficiency of the WiCS system, which is powered by a battery with a 10-year lifespan.
The WiCS technology, which recently began clinical trials, is the first truly wireless pacing device. It was developed to eliminate cardiac pacing leads, historically a major source of complications and reliability issues. Continue reading
Medical Product Manufacturing News announced that ST Microelectronics is developing ultra-low-power Systems On Chip (SOCs) suitable for implantable medical devices. ST Microelectronics’ 65nm features a Vt of only 0.6V that can be used very near threshold. The REISC processor consumes barely 10.8pJ/cycle at 0.6V. This type of technology will certainly enable many new implantable devices that must operate at extremely low powers and squeeze every bit of juice out of their batteries or energy-harvesting means. Click here for link to article.
Intermedics’ next-generation pacing platform would have been full of neat features such as: hemodynamic sensing (impedance-based hemodynamic sensor), autocapture (capture verification), autothreshold (self-tuning based on automatic strength-duration curve generation), high-quality digital telemetry, large-volume memory for electrogram storage, non-volatile memory for self-recovery and patient information, advanced noise detection, etc. My favorite feature though was “Patient Alert”. That saddle-shaped electrode in the picture was used to stimulate the patient’s pectoral muscles whenever the pacemaker wanted to alert the patient of a problem (e.g. low battery, fractured lead, etc.). The project was canceled when Guidant (now Boston Scientific) purchased Intermedics in 1998.
MetaCure’s TANTALUS II device is an advanced implantable electrical stimulator used to apply gastric stimulation. It works by enhancing the activity of gastric muscles only when the patient eats, which modifies hormone secretion, favorably affecting glucose and fat metabolism. At the same time, the stimulation causes the patient to feel satiated sooner and consume less food. The result is an improvement in blood glucose levels, which is often accompanied by weight loss, and reduction of blood pressure, waist circumference and blood lipid level. Continue reading
Impulse Dynamics’ OPTIMIZER™ III Implantable Pulse Generator delivers Cardiac Contractility Modulation (CCM), non-excitatory electrical signals during the myocardial absolute refractory period in synchrony with locally sensed electrical activity. CCM signals are intended to treat patients with symptomatic heart failure despite appropriate medical treatment. Continue reading
Welcome to implantable-device.com, a blog dedicated to professionals interested in the fascinating world of active implantable medical devices!
Let me tell you a bit about myself: I have over twenty-five years of experience in the design of Medical Electronic Instrumentation, most of it developing active implantable medical devices. In addition to over 40 papers and 80 patents on implantable medical devices, I am the lead author of the books “Design and Development of Medical Electronic Instrumentation”, “Exploring Quantum Physics Through Hands-On Projects,” and “Exploring Ultraviolet Photography – Bee Vision, Forensic Imaging, and Other Adventures in Ultraviolet Photography.”
Please contact me if you would like to contribute to the blog, correct information that you find in these pages, make a news release, or if you have a picture of an implantable device that you would like to share with everyone else.
I hope that you enjoy reading and participating in this blog!
David Prutchi, Ph.D.