Precis GmbH is a German company headquartered in Heidelberg developing neuromodulation systems. On September 15, 2022, Precis received the CE Mark for its EASEE® system for treating adults with therapy-refractory focal epilepsies.
The EASEE® implant consists of a thin electrode pad that is implanted under the skin of the scalp and an IPG that is is implanted in the chest area and connected to the electrode pad with a cable.
Precis’ electrode design is claimed to produce deep and focused stimulation of the brain. According to Precis’ website:
“A so-called Laplace electrode generates fields and current flows perpendicular to the electrode pad. In the EASEE® System, the external ring-shaped electrode is replaced by four individual electrodes in order to adapt the direction of the resultant electrical field to spatially varying resistances. In this way, significant current flows can be achieved on the surface of the brain as well as a penetration depth comparable to that of more invasive procedures.”
JAMA Neurology published a paper on April 4, 2023 detailing clinical results with the EASEE® System. After six months’ active treatment, 53% of patients demonstrated a full response to the device, as defined by a reduction in seizure frequency of at least 50% below baseline. 84% of patients demonstrated a response of some kind. There were no serious events reported which were related to either the device or its implantation. A summary is available here.